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Intravitreal ketorolac for the treatment of chronic cystoid macular edema after cataract surgery

Authors Tsilimbaris MK, Tsika C, Kymionis GD

Received 29 September 2015

Accepted for publication 6 November 2015

Published 12 February 2016 Volume 2016:12 Pages 177—182

DOI https://doi.org/10.2147/TCRM.S97342

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Hoa Le

Peer reviewer comments 3

Editor who approved publication: Professor Garry Walsh

Miltiadis K Tsilimbaris, Chrysanthi Tsika, George D Kymionis

Department of Ophthalmology, University of Crete, Heraklion, Greece

Purpose: To report two cases of chronic postoperative cystoid macular edema, resistant to topical therapy, treated with consecutive intravitreal injections of ketorolac tromethamine.
Methods: Four daily intravitreal injections of 500 µg/0.05 mL of ketorolac were given to each patient. Complete clinical examination and OCT were performed before every injection, 1, 2, 3 weeks, and 1, 3, and 6 months after the last injection. Fluorescein angiography was performed at baseline examination, 1, 3, and 6 months after the last injection.
Results: In both cases, the edema regressed and visual acuity increased. At 6 months after the last injection, the leakage was significantly reduced at the fluorescein angiography.
Discussion: Both cases responded favorably to the consecutive intravitreal administration of ketorolac tromethamine. The long-lasting remission of the macular edema in these chronic cases underlines the therapeutic potential of these agents when delivered intravitreally.

Keywords: postoperative CME, intravitreal, ketorolac, NSAIDs

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