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Intravitreal injection of tissue plasminogen activator as treatment for an occluded pars plana glaucoma tube

Authors Tsui I, Airiani S, Wen A, El-Sawy T, Fine HF, Maris Jr PJ

Published 10 September 2008 Volume 2009:3 Pages 91—93


Review by Single anonymous peer review

Peer reviewer comments 1

Irena Tsui, Suzanna Airiani, Angie Wen, Tarek El-Sawy, Howard F Fine, Peter JG Maris Jr

Department of Ophthalmology, Columbia University, New York, NY, USA

Abstract: Implanting glaucoma tubes through the pars plana in the setting of a corneal transplant is becoming more common, and there are unique problems associated with such a procedure. A 42-year-old man with multiple previous eye surgeries presented with a nonfunctioning pars plana glaucoma tube. There was no view to the tube tip, but it was presumed to be clogged with fibrin. Intravitreal tissue plasminogen activator (tPA) was injected through the pars plana which resulted in intraocular pressure control without further surgery. This new application of intravitreal tPA has not been reported previously. Future research should investigate the optimal effective and safe dose of intravitreal tPA injection to relieve such occlusions.

Keywords: tissue plasminogen activator (tPA), Ahmed Glaucoma Valve

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