Back to Journals » Clinical Ophthalmology » Volume 5

Intravitreal gas injection for the treatment of diabetic macular edema

Authors McHugh D, Gupta B, Saeed M

Published 26 October 2011 Volume 2011:5 Pages 1543—1548

DOI https://doi.org/10.2147/OPTH.S25348

Review by Single-blind

Peer reviewer comments 6


Dominic McHugh, Bhaskar Gupta, Manzar Saeed
King's College Hospital, Denmark Hill, London, England, UK

Purpose: This study investigates the efficacy of an intravitreal gas injection in inducing a posterior vitreous detachment (PVD) in patients with clinically significant diabetic macular edema refractory to laser therapy.
Methods: A local ethics committee-approved technique of an intravitreal injection of pure perfluoropropane gas (C3F8) was performed for all participants. After a period of prone positioning, the patients underwent regular and detailed clinical review.
Main outcome measures: The induction of a PVD, change in macular thickness, change in visual acuity.
Results: A PVD was induced in all five eyes with subsequent signs of reduction in macular thickness and resolution of exudates. Mean visual improvement was 11 ETDRS (Early Treatment Diabetic Retinopathy Study) letters (range 4–21). Apart from a transient vitreous hemorrhage in one eye, there were no significant treatment-related complications.
Conclusion: The induction of a PVD by pneumatic retinopexy appears to have a significant influence on diabetic macular edema in eyes which have not successfully responded to macular laser therapy. A randomized clinical trial is justified on the basis of the initial promising data.

Keywords: optical coherence tomography, OCT, posterior vitreous detachment, perfluoropropane

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]