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Intravenous paracetamol and intraocular pressure reduction: mannitol may also be involved

Authors Allegaert K

Received 2 August 2016

Accepted for publication 4 August 2016

Published 15 September 2016 Volume 2016:10 Pages 1775—1777

DOI https://doi.org/10.2147/OPTH.S118752

Checked for plagiarism Yes

Editor who approved publication: Dr Scott Fraser


Karel Allegaert1,2

1Intensive Care, Department of Surgery, Erasmus MC Sophia Children’s Hospital, Rotterdam, the Netherlands; 2Department of Development and Regeneration, KU Leuven, Belgium


I read, with great interest, the paper on the intraocular pressure-lowering properties of intravenous paracetamol (acetaminophen) recently published in this journal by van den Heever and Meyer.1 The authors documented a decrease from baseline in mean intraocular pressure of 15.7% in a 6-hour time interval following intravenous paracetamol (1 g Perfalgan®, Bristol-Myers Squibb, New York, NY, USA) administration. This mean decrease was moderate but relevant when compared to, for example, topical timolol (–25.3%, single drop 0.5% timolol maleate) or oral acetazolamide (–23.1%, 250 mg). Although the authors provided potential relevant mechanistic arguments in support of a link between paracetamol administration and intraocular pressure through the endocannabinoid system, we would like to draw attention to the fact that – when intravenous paracetamol is administered – a relevant amount of mannitol is coadministered.

View the original paper by van den Heever and Meyer


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