Back to Browse Journals » International Journal of Nanomedicine » Volume 8 » Issue 1

Intravenous magnetic nanoparticle cancer hyperthermia

Authors Huang HS, Hainfeld JF

Received 7 February 2013

Accepted for publication 22 March 2013

Published 17 July 2013 Volume 2013:8(1) Pages 2521—2532


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Video abstract presented by HS Huang and JF Hainfeld.

Views: 1274

Hui S Huang, James F Hainfeld

Nanoprobes, Yaphank, NY, USA

Abstract: Magnetic nanoparticles heated by an alternating magnetic field could be used to treat cancers, either alone or in combination with radiotherapy or chemotherapy. However, direct intratumoral injections suffer from tumor incongruence and invasiveness, typically leaving undertreated regions, which lead to cancer regrowth. Intravenous injection more faithfully loads tumors, but, so far, it has been difficult achieving the necessary concentration in tumors before systemic toxicity occurs. Here, we describe use of a magnetic nanoparticle that, with a well-tolerated intravenous dose, achieved a tumor concentration of 1.9 mg Fe/g tumor in a subcutaneous squamous cell carcinoma mouse model, with a tumor to non-tumor ratio > 16. With an applied field of 38 kA/m at 980 kHz, tumors could be heated to 60°C in 2 minutes, durably ablating them with millimeter (mm) precision, leaving surrounding tissue intact.

Keywords: magnetic nanoparticles, hyperthermia, cancer, alternating magnetic field, intravenous delivery

Download Article [PDF] View Full Text [HTML] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at:

Readers of this article also read:

Nanofabrication of methylglyoxal with chitosan biopolymer: a potential tool for enhancement of its anticancer effect

Pal A, Talukdar D, Roy A, Ray S, Mallick A, Mandal C, Ray M

International Journal of Nanomedicine 2015, 10:3499-3518

Published Date: 12 May 2015

Efficacy and feasibility of the immunomagnetic separation based diagnosis for detecting sentinel lymph node metastasis from breast cancer

Zhi XC, Zhang M, Meng TT, Zhang XB, Shi ZD, Liu Y, Liu JJ, Zhang S, Zhang J

International Journal of Nanomedicine 2015, 10:2775-2784

Published Date: 7 April 2015

In vitro evaluation of endothelial exosomes as carriers for small interfering ribonucleic acid delivery

Banizs AB, Huang T, Dryden K, Berr SS, Stone JR, Nakamoto RK, Shi W, He J

International Journal of Nanomedicine 2014, 9:4223-4230

Published Date: 3 September 2014

Nanostructured lipid carrier-loaded hyaluronic acid microneedles for controlled dermal delivery of a lipophilic molecule

Lee SG, Jeong JH, Lee KM, Jeong KH, Yang H, Kim M, Jung H, Lee S, Choi YW

International Journal of Nanomedicine 2014, 9:289-299

Published Date: 31 December 2013

Cancer stem cell theory: therapeutic implications for nanomedicine

Wang K, Wu X, Wang J, Huang J

International Journal of Nanomedicine 2013, 8:899-908

Published Date: 28 February 2013

Anti-CD30-targeted gold nanoparticles for photothermal therapy of L-428 Hodgkin's cell

Qu X, Yao C, Wang J, Li Z, Zhang Z

International Journal of Nanomedicine 2012, 7:6095-6103

Published Date: 14 December 2012

The western diet and lifestyle and diseases of civilization

Pedro Carrera-Bastos, Maelan Fontes-Villalba, James H O’Keefe, et al

Research Reports in Clinical Cardiology 2011, 2:15-35

Published Date: 9 March 2011

Case of endogenous endophthalmitis caused by Streptococcus equisimilis

Shinsuke Suemori, Akira Sawada, Shinya Komori, et al

Clinical Ophthalmology 2010, 4:917-918

Published Date: 12 August 2010