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Intravenous buprenorphine/naloxone and concomitant oral pregabalin misuse: a case report

Authors Kulaksizoğlu B, Kara H, Bodur B, Kuloğlu M

Received 16 July 2018

Accepted for publication 19 October 2018

Published 9 November 2018 Volume 2018:14 Pages 3033—3035


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Dr Roger Pinder

Burak Kulaksizoğlu,1,2 Hüseyin Kara,1,2 Berkan Bodur,1,2 Murat Kuloğlu1,2

1Department of Psychiatry, Akdeniz University School of Medicine, Antalya, Turkey; 2Akdeniz University, Alcohol and Substance Addiction Treatment and Research Center, Antalya, Turkey

Abstract: Opioid misuse and dependence are major medical and social concerns worldwide. Buprenorphine/naloxone combination (BNC) is a drug that has misuse potential and is used to treat opioid dependence, including buprenorphine and naloxone. Buprenorphine shows its pharmacological effects by binding to opioid receptors. Buprenorphine is a partial agonist and has smaller maximal effects compared to those of full agonists (heroin, methadone). Naloxone is a non-selective opiate antagonist added to buprenorphine for the prevention of intravenous diversion. BNC is used in the treatment of opioid dependence for detoxification and maintenance. The drug should be used as a sublingual film tablet. Pregabalin is used in the treatment of neuropathic pain, epilepsy and anxiety disorders. It is increasingly being reported as possessing a potential for misuse. In this article, we present a case of intravenous BNC and concomitant oral pregabalin misuse that developed in a monitored and treated patient for the reason of opioid dependence.

Keywords: intravenous buprenorphine–naloxone, pregabalin, drug misuse, opioid addiction

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