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Intraoperative radiotherapy in stage IIB adenocarcinoma of the uterine cervix: a retrospective study

Authors Gao Y, Liu Z, Gao F, Chen X, Wang P

Received 15 August 2013

Accepted for publication 21 September 2013

Published 20 November 2013 Volume 2013:6 Pages 1695—1700

DOI https://doi.org/10.2147/OTT.S53020

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

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Ying Gao,1 Zi Liu,1 Fei Gao,2 Xi Chen2

1Department of Radiotherapy Oncology, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, People's Republic of China; 2Department of Surgery, Second Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, People's Republic of China

Objectives: Adenocarcinoma (AC) of the uterine cervix has a poor prognosis and is usually fatal. The aim of this study was to evaluate the clinical outcome and toxicity of intraoperative electron beam radiation therapy (IOERT) in advanced AC.
Methods: Twenty-seven women were treated with IOERT. Surgery consisted of gross negative surgical margins in 19 patients, positive surgical margins in two patients, and close surgical margins in six patients. Twenty-three patients received chemotherapy.
Results: The 5-year overall survival and disease-free survival rates were 21/27 (77.8%) and 19/27 (70.4%), respectively. A significantly better survival rate was found in patients with AC compared to patients with adenosquamous carcinoma. Tumor recurrence and metastasis were observed in seven patients (25.9%). No central failure occurred whether or not the resection margins were positive. Two (7.4%) patients developed peripheral neurotoxicity.
Conclusion: IOERT plus surgery may be feasible and effective with a low risk of toxicity, even in patients with positive resection margins.

Keywords: IOERT, recurrence, adenocarcinoma, cervical cancer

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