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Intestinal microbiota: a novel perspective in colorectal cancer biotherapeutics

Authors Ding C, Tang W, Fan X, Wu G

Received 10 April 2018

Accepted for publication 12 June 2018

Published 13 August 2018 Volume 2018:11 Pages 4797—4810

DOI https://doi.org/10.2147/OTT.S170626

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Yao Dai


Chenbo Ding,1,2 Wendong Tang,1 Xiaobo Fan,1 Guoqiu Wu1,2

1Medical School of Southeast University, Nanjing, Jiangsu Province, People’s Republic of China; 2Center of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing, Jiangsu Province, People’s Republic of China

Abstract: It is believed that genetic factors, immune system dysfunction, chronic inflammation, and intestinal microbiota (IM) dysbiosis contribute to the pathogenesis of colorectal cancer (CRC). The beneficial role played by the direct regulation of IM in inflammatory bowel disease treatment is identified by the decreased growth of harmful bacteria and the increased production of anti-inflammatory factors. Interestingly, gut microbiota has been proven to inhibit tumor formation and progression in inflammation/carcinogen-induced CRC mouse models. Recently, evidence has indicated that IM is involved in the negative regulation of tumor immune response in tumor microenvironment, which then abolishes or accelerates anticancer immunotherapy in several tumor animals. In clinical trials, a benefit of IM-based CRC therapies in improving the intestinal immunity balance, epithelial barrier function, and quality of life has been reported. Meanwhile, specific microbiota signature can modulate host’s sensitivity to chemo-/radiotherapy and the prognosis of CRC patients. In this review, we aim to 1) summarize the potential methods of IM-based therapeutics according to the recent results; 2) explore its roles and underlying mechanisms in combination with other therapies, especially in biotherapeutics; 3) discuss its safety, deficiency, and future perspectives.

Keywords: intestinal microbiota, colorectal cancer, biotherapeutic, immune response

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