International Journal of General Medicine

Uncovering the potential of MicroRNAs as biomarkers and therapeutics in Liver Disease

This Article Collection includes original and innovative contributions, and discussion of testable hypotheses, from a diverse group of clinical and basic scientists that will advance the field and unravel the puzzling complex mechanisms by which miRNAs cause, cure and exacerbate liver disease and function. For example, miRNAs are implicated in the differentiation of bone-marrow derived stem cells into hepatocytes; in the inhibition of angiogenesis by HCC; in miR-34-mediated growth arrest via direct control over the cell cycle regulator cyclin E2, and the hepatocyte growth factor receptor c-Met, augmenting caspase-dependent cell death; in miR-26 mediated suppression or increased metastasis of HCC.