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Intermittent acute angle closure glaucoma and chronic angle closure following topiramate use with plateau iris configuration

Authors Rajjoub L, Chadha N, Belyea D

Received 8 April 2014

Accepted for publication 6 May 2014

Published 17 July 2014 Volume 2014:8 Pages 1351—1354


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Lamise Z Rajjoub, Nisha Chadha, David A Belyea

Department of Ophthalmology, The George Washington University, Washington, DC, USA

Abstract: This is a case report describing recurrent intermittent acute angle closure episodes in the setting of topiramate use in a female suffering from migraines. Despite laser peripheral iridotomy placement for the pupillary block component, and the discontinuation of topiramate, the acute angle closure did not resolve in the left eye with chronic angle closure and the patient required urgent trabeculectomy. The right eye responded to laser peripheral iridotomy immediately and further improved after the cessation of topiramate. While secondary angle closure glaucoma due to topiramate use has been widely reported, its effects in patients with underlying primary angle closure glaucoma have not been discussed. Our report highlights the importance of recognizing the often multifactorial etiology of angle closure glaucoma to help guide clinical management.

Keywords: angle closure glaucoma, plateau iris, topiramate, secondary glaucoma, drug-induced glaucoma

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