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Interatrial shunt devices for heart failure with normal ejection fraction: a technology update

Authors Cuthbert JJ, Pellicori P, Clark AL

Received 13 February 2017

Accepted for publication 18 April 2017

Published 2 June 2017 Volume 2017:10 Pages 123—132

DOI https://doi.org/10.2147/MDER.S113105

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser


Joseph J Cuthbert, Pierpaolo Pellicori, Andrew L Clark

Department of Cardiology, Hull York Medical School, Hull and East Yorkshire Medical Research and Teaching Centre, Castle Hill Hospital, Cottingham, Kingston upon Hull, UK

Abstract: Heart failure with normal ejection fraction (HeFNEF) accounts for ~50% of heart failure admissions. Its pathophysiology and diagnostic criteria are yet to be defined clearly which may hinder the search for effective treatments. The clinical hallmark of HeFNEF is exertional breathlessness, often due to an abnormal increase in left atrial pressure during exercise. Creation of an interatrial communication to offload the left atrium is a possible therapeutic approach. There are two percutaneously delivered devices currently under investigation which are discussed in this review.

Keywords: IASD, V-Wave, device therapy, HeFNEF, review, preserved EF, HeFPEF, HFpEF

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