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Interaction between dietary patterns and TCF7L2 polymorphisms on type 2 diabetes mellitus among Uyghur adults in Xinjiang Province, China

Authors Cai J, Zhang Y, Nuli R, Zhang Y, Abudusemaiti M, Kadeer A, Tian X, Xiao H

Received 22 October 2018

Accepted for publication 22 December 2018

Published 14 February 2019 Volume 2019:12 Pages 239—255

DOI https://doi.org/10.2147/DMSO.S191759

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Dr Konstantinos Tziomalos


Junxiu Cai,1,2,* Yan Zhang,3,* Rebiya Nuli,4 Yangyi Zhang,5 Manfutong Abudusemaiti,5 Aizhatiguli Kadeer,6 Xiaoli Tian,5 Hui Xiao5

1Department of Occupational and Environmental Health, School of Public Health, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China; 2Medical Department, Fifth Affiliated Hospital, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China; 3Department of Pathology, Basic Medical Science Institute, International Education College, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China; 4Department of Human Parasitology, Basic Medical Science Institute, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China; 5Department of Nutrition and Food Hygiene, School of Public Health, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China; 6Department of Epidemiology and Statistics, School of Public Health, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China

*These authors contributed equally to this work

Purpose: This study aimed to characterize dietary patterns in the Uyghur population and examined the relationship between dietary pattern, TCF7L2 single-nucleotide polymorphisms (SNPs), and the risk of type 2 diabetes mellitus (T2DM).
Patients and methods: Dietary patterns were defined using factor analysis, and associations between dietary patterns were evaluated using multivariate logistic regression analyses. Genotyping of seven SNPs of TCF7L2 (rs11196205, rs12255372, rs12573128, rs4506565, rs7895340, rs7901695, and rs7903146) was conducted, and the association between these seven SNPs and the risk of T2DM was evaluated. Interactions between SNPs, homeostasis model assessment-insulin resistance, and dietary patterns were also analyzed.
Results: A total of 828 participants were enrolled in this study, including 491 people with T2DM and 337 healthy controls. Five dietary patterns were defined, and the results indicated that the “fruit” and “vegetables” dietary patterns were associated with a significant decrease in the risk of T2DM, whereas the “meats” and “grains” dietary patterns were associated with an increased risk of T2DM. Moreover, the “dairy product” dietary pattern showed no association with the risk of T2DM. Furthermore, our results revealed that the TCF7L2 SNP, rs12573128, is associated with an increased risk of T2DM. SNPs rs4506565 and rs7903146 significantly interacted with dietary pattern.
Conclusion: Our studies suggest that dietary pattern and genetic polymorphisms of TCF7L2 are associated with the development of T2DM in the Uyghur population of China.

Keywords: type 2 diabetes mellitus, dietary patterns, TCF7L2, polymorphism, Uyghur
 

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