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Integrative systems of genomic risk markers for cancer and other diseases: future of predictive medicine

Authors Yuzhalin A, Kutikhin A

Received 14 February 2012

Accepted for publication 9 April 2012

Published 23 May 2012 Volume 2012:4 Pages 131—135

DOI https://doi.org/10.2147/CMAR.S30855

Review by Single-blind

Peer reviewer comments 5


Arseniy E Yuzhalin, Anton G Kutikhin

Department of Epidemiology, Kemerovo State Medical Academy, Kemerovo, Russian Federation

Abstract: This paper focuses on genomic predictive biomarkers in medicine. It is known that single nucleotide polymorphisms of genes involved in the pathogenesis of various diseases, including cancer, can serve as indicators of risk warranting further diagnostics, screening, and early prevention measures. However, although ten million single nucleotide polymorphisms have been identified to date, the majority of them do not appear to have a relationship with risk of development of pathogenic processes in the human body. The concept of selection of significant disease-associated biomarkers is proposed. Also, future development of integrative systems of genomic risk markers is discussed.

Keywords: biomarkers, cancer, single nucleotide polymorphisms, cancer prevention

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