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Intake consumption of ginsenoside Rg3, profiling of selected cytokines, and development of rectal polyps

Authors Xie J, Luo S, Mi H, Du Y, Bao G, Zhou J, Xi Y, Li C

Received 5 December 2018

Accepted for publication 27 February 2019

Published 6 May 2019 Volume 2019:11 Pages 4059—4064

DOI https://doi.org/10.2147/CMAR.S197097

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Professor Lu-Zhe Sun


Jian Xie,1 Shicheng Luo,2 Hongying Mi,3 Yibin Du,4 Guohong Bao,1 Jing Zhou,1 Yumei Xi,1 Cichun Li5

1Department of Traditional Chinese Medicine and Anorectum, The First People’s Hospital of Yunnan Province, Kunming 650000, People’s Republic of China; 2Department of General Surgery, The First People’s Hospital of Yunnan Province, Kunming 650000, People’s Republic of China; 3Department of Pediatrics, First People’s Hospital of Yunnan Province, Kunming 650000, People’s Republic of China; 4Department of Geriatrics, The First Affiliated Hospital of Yunnan College of Traditional Chinese Medicine, Kunming 650000, People’s Republic of China; 5Department of Traditional Chinese Medicine and Anorectum, The Second Affiliated Hospital of Kunming Medical University, Kunming 650000, People’s Republic of China

Background: Rectal polyps is a major risk factor for rectal cancer. There is a need to explore a panel of preventive measures, as well as reliable biomarkers for screening of rectal polyps.
Patients and methods: We conducted a case control study which aimed to explore the effects of regular consumption of ginsenoside Rg3, profiling of selected cytokines, and development of rectal polyps in a Chinese population.
Results: Significantly higher levels of IL-4, MIP-1β, FasL, TGF-β1, and RANTES were detected in rectal polyp cases. Further, we found significant dose-response relationships between quartile-categorized levels of IL-4, MIP-1β, FasL, and TGF-β1, and risk of rectal polyps. The strongest associations for IL-4, MIP-1β, FasL, and TGF-β1 were observed for the highest quartile vs the lowest quartile with an OR of 1.78, 2.70, 1.49, and 2.36, respectively. Compared with non-Rg3 consumers, regular Rg3 consumers had a significantly lower risk of rectal polyps (OR =0.71; 95% CI: 0.55–0.92; P=0.009). We also found that Rg3 consumers had significantly lower levels of IL-4, MIP-1β, FasL, and TGF-β1 than non-Rg3 consumers, in both rectal polyp cases and healthy controls.
Conclusion: These results indicate that regular consumption of Rg3 might prevent the occurrence of rectal polyps through decreasing the serum level of selected cytokines, including IL-4, MIP-1β, FasL, and TGF-β1. Further clinical trials and prospective cohort studies with larger sample sizes are warranted to validate the anti-inflammatory activity and the anti-tumorigenic role of Rg3.

Keywords: cytokine, Rg3, rectal polyps, IL-4, MIP-1β, FasL, TGF-β1

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