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Inotuzumab ozogamicin in the treatment of relapsed/refractory acute B cell lymphoblastic leukemia

Authors Uy N, Nadeau M, Stahl M, Zeidan AM

Received 19 November 2017

Accepted for publication 13 March 2018

Published 13 April 2018 Volume 2018:9 Pages 67—74

DOI https://doi.org/10.2147/JBM.S136575

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 4

Editor who approved publication: Dr Martin Bluth


Natalie Uy, Michelle Nadeau, Maximilian Stahl, Amer M Zeidan

Section of Hematology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA

Abstract: The improvement in outcomes of adult patients with acute lymphoblastic leukemia (ALL) has been modest, with the exception of Philadelphia chromosome-positive disease, despite advances in supportive care and stem cell transplantation. The recent approvals of novel agents, including the bispecific T-cell engager blinatumomab, the antibody-drug conjugate inotuzumab ozogamicin, and chimeric antigen receptor T-cell products are changing the management of B-ALL, which traditionally relied on chemotherapy-based approaches. Inotuzumab ozogamicin is a humanized CD22 monoclonal antibody linked to the cytotoxic agent calicheamicin. CD22 is expressed on leukemic blasts in >90% of ALL patients, and inotuzumab ozogamicin has shown excellent clinical activity even among heavily pretreated relapsed/refractory (R/R) B-ALL patients and elderly B-ALL patients. Clinical trials have shown superior survival with the drug over chemotherapy-based approaches in the first- or second-line salvage therapy for relapsed B-ALL as monotherapy. Currently, new trials are evaluating inotuzumab ozogamicin in the frontline setting in combination-based approaches. In this review, we summarize the preclinical and clinical data of inotuzumab ozogamicin in R/R B-ALL and foresee the future use of this drug in the clinic.

Keywords: inotuzumab ozogamicin, CD22, monoclonal antibodies, acute lymphoblastic leukemia, antibody-drug conjugate

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