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Inhibition of the Soluble Epoxide Hydrolase as an Analgesic Strategy: A Review of Preclinical Evidence

Authors Wang Y, Wagner KM, Morisseau C, Hammock BD

Received 13 October 2020

Accepted for publication 8 December 2020

Published 13 January 2021 Volume 2021:14 Pages 61—72

DOI https://doi.org/10.2147/JPR.S241893

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Michael Schatman


Yuxin Wang, Karen M Wagner, Christophe Morisseau, Bruce D Hammock

Department of Entomology and Nematology, UC Davis Comprehensive Cancer Center, University of California Davis, Davis, CA 95616, USA

Correspondence: Bruce D Hammock Email bdhammock@ucdavis.edu

Abstract: Chronic pain is a complicated condition which causes substantial physical, emotional, and financial impacts on individuals and society. However, due to high cost, lack of efficacy and safety problems, current treatments are insufficient. There is a clear unmet medical need for safe, nonaddictive and effective therapies in the management of pain. Epoxy-fatty acids (EpFAs), which are natural signaling molecules, play key roles in mediation of both inflammatory and neuropathic pain sensation. However, their molecular mechanisms of action remain largely unknown. Soluble epoxide hydrolase (sEH) rapidly converts EpFAs into less bioactive fatty acid diols in vivo; therefore, inhibition of sEH is an emerging therapeutic target to enhance the beneficial effect of natural EpFAs. In this review, we will discuss sEH inhibition as an analgesic strategy for pain management and the underlying molecular mechanisms.

Keywords:  epoxy fatty acids, chronic pain, molecular mechanisms

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