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Inhalation drug delivery devices: technology update

Authors Ibrahim M, Verma R, Garcia-Contreras L

Received 20 August 2014

Accepted for publication 7 October 2014

Published 12 February 2015 Volume 2015:8 Pages 131—139

DOI https://doi.org/10.2147/MDER.S48888

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Dr Scott Fraser


Mariam Ibrahim, Rahul Verma, Lucila Garcia-Contreras

Department of Pharmaceutical Sciences, College of Pharmacy, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

Abstract: The pulmonary route of administration has proven to be effective in local and systemic delivery of miscellaneous drugs and biopharmaceuticals to treat pulmonary and non-pulmonary diseases. A successful pulmonary administration requires a harmonic interaction between the drug formulation, the inhaler device, and the patient. However, the biggest single problem that accounts for the lack of desired effect or adverse outcomes is the incorrect use of the device due to lack of training in how to use the device or how to coordinate actuation and aerosol inhalation. This review summarizes the structural and mechanical features of aerosol delivery devices with respect to mechanisms of aerosol generation, their use with different formulations, and their advantages and limitations. A technological update of the current state-of-the-art designs proposed to overcome current challenges of existing devices is also provided.

Keywords: pulmonary delivery, asthma, nebulizers, metered dose inhaler, dry powder inhaler

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