Back to Journals » International Journal of Nanomedicine » Volume 7

Influences of surface coatings and components of FePt nanoparticles on the suppression of glioma cell proliferation

Authors Sun H, Chen X, Chen D, Dong M, Fu X, Li Q, Liu X, Wu Q, Qiu T, Wan T, Li S

Received 6 April 2012

Accepted for publication 14 May 2012

Published 6 July 2012 Volume 2012:7 Pages 3295—3307


Review by Single-blind

Peer reviewer comments 3

Haiming Sun,1,* Xiaohui Chen,2,* Dan Chen,1 Mingyan Dong,1 Xinning Fu,1 Qian Li,1 Xi Liu,1 Qingzhi Wu,1 Tong Qiu,1 Tao Wan,1 Shipu Li1

1State Key Laboratory of Advanced Technology for Materials Synthesis and Processing and Biomedical Materials and Engineering Center, Wuhan University of Technology, Wuhan, China; 2Department of Prosthetics, School of Stomatology, Wuhan University, Wuhan, China

*Both authors contributed equally to this work

Abstract: Malignant gliomas are primary brain tumors with high rates of morbidity and mortality; they are the fourth most common cause of cancer death. Novel diagnostic and therapeutic techniques based on nanomaterials provide promising options in the treatment of malignant gliomas. In order to evaluate the potential of FePt nanoparticles (NPs) for malignant glioma therapy, FePt NPs with different surface coatings and components were tunably synthesized using oleic acid/oleylamine (OA/OA) and cysteines (Cys) as the capping agents, respectively. The samples were characterized using X-ray diffraction, transmission electron microscopy (TEM), X-ray photon spectroscopy, Fourier transform infrared spectroscopy, atomic absorption spectrum, and zeta potential. The influence of the surface coatings and components of the FePt NPs on the proliferation of glioma cells was assessed through MTT assay and TEM observation using three typical glioma cell lines (glioma U251 cells, astrocytoma U87 cells, and neuroglioma H4 cells) as in vitro models. The results showed that the proliferation of glioma cells was significantly suppressed by lipophilic FePt-OA/OA NPs in a time- and/or dose-dependent manner, while no or low cytotoxic effects were detected in the case of hydrophilic FePt-Cys NPs. The IC50 value of FePt-OA/OA NPs on the three glioma cell lines was approximately 5–10 µg mL-1 after 24 hours’ incubation. Although the cellular uptake of FePt NPs was confirmed regardless of the surface coatings and components of the FePt NPs, the suppression of FePt NPs on glioma cell proliferation was dominantly determined by their surface coatings rather than their components. Therefore, these results demonstrate that, through engineering of the surface coating, FePt NPs can potentially be developed as novel therapeutic agents for malignant gliomas.

Keywords: FePt nanoparticles, surface coatings, compositions, glioma cells, proliferation

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]


Other article by this author:

Water-soluble l-cysteine-coated FePt nanoparticles as dual MRI/CT imaging contrast agent for glioma

Liang SY, Zhou Q, Wang M, Zhu YH, Wu QZ, Yang XL

International Journal of Nanomedicine 2015, 10:2325-2333

Published Date: 23 March 2015

Readers of this article also read:

Evaluation of calcified carotid atheroma on panoramic radiographs and Doppler ultrasonography in an older population

Atalay Y, Asutay F, Agacayak KS, Koparal M, Adali F, Gulsun B

Clinical Interventions in Aging 2015, 10:1121-1129

Published Date: 8 July 2015

Reversible brain atrophy and cognitive impairment in an adolescent Japanese patient with primary adrenal Cushing’s syndrome

Ohara N, Suzuki H, Suzuki A, Kaneko M, Ishizawa M, Furukawa K, Abe T, Matsubayashi Y, Yamada T, Hanyu O, Shimohata T, Sone H

Neuropsychiatric Disease and Treatment 2014, 10:1763-1767

Published Date: 15 September 2014

Schizophrenia relapse and the clinical usefulness of once-monthly aripiprazole depot injection

Wang SM, Han C, Lee SJ, Patkar AA, Masand PS, Pae CU

Neuropsychiatric Disease and Treatment 2014, 10:1605-1611

Published Date: 30 August 2014

A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone

Hu Z, Liao M, Chen Y, Cai Y, Meng L, Liu Y, Lv N, Liu Z, Yuan W

International Journal of Nanomedicine 2012, 7:5719-5724

Published Date: 12 November 2012

Degradable copolymer based on amphiphilic N-octyl-N-quatenary chitosan and low-molecular weight polyethylenimine for gene delivery

Liu CC, Zhu Q, Wu WH, Xu XL, Wang XY, Gao S, Liu KH

International Journal of Nanomedicine 2012, 7:5339-5350

Published Date: 8 October 2012

Biofunctionalization of a titanium surface with a nano-sawtooth structure regulates the behavior of rat bone marrow mesenchymal stem cells

Zhang WJ, Li ZH, Liu Y, Ye DX, Li JH, Xu LY, Wei B, Zhang XL, Liu XY, Jiang XQ

International Journal of Nanomedicine 2012, 7:4459-4472

Published Date: 13 August 2012

Plasmid-encapsulated polyethylene glycol-grafted polyethylenimine nanoparticles for gene delivery into rat mesenchymal stem cells

Chen XA, Zhang LJ, He ZJ, Wang WW, Xu B, Zhong Q, Shuai XT, Yang LQ, Deng YB

International Journal of Nanomedicine 2011, 6:843-853

Published Date: 21 April 2011