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Influence of Simvastatin-Strontium-Hydroxyapatite Coated Implant Formed by Micro-Arc Oxidation and Immersion Method on Osteointegration in Osteoporotic Rabbits
Authors Zhao B, Li X, Xu H, Jiang Y, Wang D, Liu R
Received 5 January 2020
Accepted for publication 6 March 2020
Published 16 March 2020 Volume 2020:15 Pages 1797—1807
DOI https://doi.org/10.2147/IJN.S244815
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Linlin Sun
Baodong Zhao,1,2 Xin Li,1,2 Hao Xu,1,2 Yaping Jiang,1,2 Dashan Wang,1,2 Ran Liu1,2
1Department of Oral Implantology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266001, People’s Republic of China; 2School of Stomatology, Qingdao University, Qingdao, Shandong 266001, People’s Republic of China
Correspondence: Xin Li
The Affiliated Hospital of Qingdao University No. 59 Haier Road, Laoshan District, Qingdao, Shandong 266001, People’s Republic of China
Tel +86532-82913583
Email lixindentist@126.com
Purpose: Enhancing osteointegration of implants in osteoporosis patients is a necessity since implantations frequently fail in these patients. The aim of this work is to study how simvastatin-strontium-hydroxyapatite coated implants perform in rabbits with osteoporosis.
Materials and Methods: Crystalline HA and Sr-HA oxide film were prepared through micro-arc oxidation. Surface characterization including morphology, roughness, element composition, phase composition, hydrophilicity were then evaluated. Simvastatin loaded on porous films through immersion, and the effects of coatings on osteointegration in osteoporotic rabbits were investigated. All samples were obtained after 4, 8 and 12 weeks of healing. Some of them were subjected to biomechanical tests and others were subjected to histological and histomorphometric analysis.
Results: Coatings exhibited a microporous network structure with appropriate roughness and high hydrophilicity. Compared to control HA and machined surface implants, simvastatin-Sr-HA coated implants exhibited marked improvements in osteointegration, which is characterized by a quicker mineralization deposition rate, good bone formation mode (large amount of contact osteogenesis and a small amount of distance osteogenesis) and increased bone-to-implant contact and pull-out strength.
Conclusion: These biological parameters demonstrate the excellent osteoconductivity of simvastatin-Sr-HA coatings in the osteoporotic state. Overall, this suggests that simvastatin-Sr-HA coatings would be applicable in poor-quality bones of patients experiencing osteoporosis.
Keywords: osteoporosis, micro-arc oxidation, strontium, simvastatin, osteointegration, dental implants
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