Back to Journals » Vascular Health and Risk Management » Volume 10

Influence of serological factors and BMI on the blood pressure/hematocrit association in healthy young men and women

Authors Vázquez BY, Vázquez MA, Chávez-Negrete A, Escobedo G, Cabrales P, Subramaniam S, Intaglietta M, Pérez-Tamayo R

Received 5 January 2014

Accepted for publication 24 February 2014

Published 6 May 2014 Volume 2014:10 Pages 271—277


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Beatriz Y Salazar Vázquez,1,2,5 Miguel A Salazar Vázquez,2,3 Adolfo Chávez-Negrete,4 Galileo Escobedo,2 Pedro Cabrales,5 Shankar Subramaniam,5 Marcos Intaglietta,5 Ruy Pérez-Tamayo2

1Faculty of Medicine, Universidad Juárez del Estado de Durango, Victoria de Durango, Dgo, Mexico; 2Department of Experimental Medicine, Faculty of Medicine, Universidad Nacional Autónoma de México, Hospital General de México Dr Eduardo Liceaga, México City, Mexico; 3Department of Pediatrics, Hospital General de Zona No. 1, Instituto Mexicano del Seguro Social, Durango, Dgo, Mexico; 4Hospital de Especialidades, Instituto Mexicano de Seguro Social, México DF, Mexico; 5Department of Bioengineering, University of California, San Diego, CA, USA

Abstract: The association between mean arterial blood pressure (MAP) and hematocrit (Hct) as a surrogate for blood viscosity was investigated in a young (average 20.0±2.3 years), healthy population of 174 men and 442 women. Health status was assessed by clinical examination and serological evaluation. Individuals with severe anemia or hemoconcentration, prior traumas or major surgical intervention, smokers, and pregnant or lactating women were excluded from the study. The MAP/Hct association was positive and significant (P=0.04) for women and negative, albeit not significantly so, for men. The MAP/Hct association was also evaluated in subgroups of the same population with a progressive step-by-step exclusion of: individuals with cholesterol >200 mg/dL; triglycerides >200 mg/dL; body mass index >25 kg/m2; and glucose >100 mg/dL. This consecutively reduced the strength of the positive MAP/Hct association in women, which became negative – although not significantly so – when all anomalously high factors were excluded. The same trend was found in men. Our study indicates that previously reported positive trends in the relationship between the MAP and Hct in the population are not present in a young, healthy population of men or women that excludes individuals with the confounding factors of above normal serological values and BMI.

Keywords: blood pressure, blood viscosity, hematocrit, vascular resistance, endothelial dysfunction

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]