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Influence of nanomaterials on stem cell differentiation: designing an appropriate nanobiointerface

Authors Ilie I, Ilie R, Mocan T, Bartos D, Mocan L

Received 16 January 2012

Accepted for publication 15 February 2012

Published 27 April 2012 Volume 2012:7 Pages 2211—2225

DOI https://doi.org/10.2147/IJN.S29975

Review by Single-blind

Peer reviewer comments 2

Ioana Ilie1, Razvan Ilie2, Teodora Mocan3, Dana Bartos4, Lucian Mocan4
1Department of Endocrinology, 2Department of Microbiology, 3Department of Physiology, 4Third Surgery Clinic, Department of Nanomedicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania

Abstract: During the last decade, due to advances in functionalization chemistry, novel nanobiomaterials with applications in tissue engineering and regenerative medicine have been developed. These novel materials with their unique physical and chemical properties are bioactive hierarchical structures that hold great promise for future development of human tissues. Thus, various nanomaterials are currently being intensively explored in the directed differentiation of stem cells, the design of novel bioactive scaffolds, and new research avenues towards tissue regeneration. This paper illustrates the latest achievements in the applications of nanotechnology in tissue engineering in the field of regenerative medicine.

Keywords: nanotechnology, nanomaterials, tissue engineering, regeneration, stem cell differentiation

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