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Influence of Body Mass Index on Survival and Prognosis in Squamous Cell Carcinoma of Head and Neck

Authors Li P, Sun L, Sun L

Received 14 February 2020

Accepted for publication 22 April 2020

Published 7 May 2020 Volume 2020:12 Pages 3203—3210

DOI https://doi.org/10.2147/CMAR.S249775

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Eileen O'Reilly


Peng Li,1 Liyan Sun,2 Luyan Sun3

1Department of Head Neck and Thyroid Surgery, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China; 2Department of Orthodontics, SATH Hospital of Stomatology, Henan University , Zhengzhou, People’s Republic of China; 3Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China

Correspondence: Peng Li
Department of Head Neck and Thyroid Surgery, Affiliated Cancer Hospital of Zhengzhou University, Jinshui District, Zhengzhou, Henan 450008, People’s Republic of China
Email zlyylipeng2383@zzu.edu.cn

Objective: Differences in body mass index (BMI) were used to analyze the survival and prognosis of SCCHN patients.
Patients and Methods: A retrospective cohort study was conducted to select 323 patients who underwent surgical treatment for SCCHN from June 2013 to June 2016. The patients were divided into a healthy BMI group (BMI< 24kg/m2), an overweight group (24kg/m2≤BMI< 28kg/m2) and an obese group (BMI≥ 28 kg/m2). Various statistical methods were used to summarize and analyze clinical data, complications, disease specific survival (DSS), the overall survival (OS), and recurrence-free survival (RFS) within the last 3 y.
Results: At 3 y, OS (54.40%) and DSS (51.94%) were slightly lower in the obese group compared with the overweight (64.62%, 61.92%) and healthy BMI groups (64.66%, 65.02%), but no statistical significance was found in DSS (P=0.178), OS (P=0.123) and RFS (P=0.362). The difference in operation duration (P=0.008) and bleeding volume (P=0.001) in obese patients was consistent with those in diabetes mellitus (P=0.002) and coronary heart disease (P=0.000). A high incidence of pharyngeal fistula was observed in obese (P=0.014) and overweight patients (P=0.025), but mouth floor fistula (P=0.038), lung infection (P=0.047), fat liquefaction (P=0.003) and lower extremities deep venous thrombosis (P=0.020) were only found in the obese group. Cox univariatable and multivariatable analysis showed that clinical stage, T stage, and N stage were independent prognostic factors for patients with SCCHN, which was not related to BMI.
Conclusion: BMI was associated with a higher probability of complications. However, BMI had no significant correlation with 3-year OS, RFS and DSS, and was not a prognostic indicator for patients with SCCHN.

Keywords: body mass index, SCCHN, DSS, OS, RFS, prognosis

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