Back to Journals » Clinical, Cosmetic and Investigational Dermatology » Volume 2

Infliximab in the treatment of plaque type psoriasis

Authors Saraceno R, Saggini A, Pietroleonardo L, Chimenti S

Published 3 April 2009 Volume 2009:2 Pages 27—37


Review by Single anonymous peer review

Peer reviewer comments 4

Rosita Saraceno, Andrea Saggini, Lucia Pietroleonardo, Sergio Chimenti

Department of Dermatology, University of Rome Tor Vergata, Rome, Viale Oxford 81, Rome, Italy

Abstract: Psoriasis is a chronic and immunomediated skin disease characterized by erythematous scaly plaques. Psoriasis affects approximately 1% to 3% of the Caucasian population. Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine that plays a critical role in the pathogenesis of psoriasis. Infliximab is an anti-TNF-α drug widely used for the treatment of plaque type psoriasis and psoriatic arthritis. Controlled clinical trials demonstrated that infliximab is characterized by a high degree of clinical response in moderate to severe plaque psoriasis. Moreover infliximab showed rapid efficacy in nail psoriasis which represents a therapeutic challenge for dermatologists and a relevant source of distress for patients with plaque psoriasis. This anti-TNF-α has an encouraging safety profile, especially as long as physicians are watchful in prevention and early diagnosis of infections and infuse reactions. The efficacy, tolerability and safety profiles suggest infliximab as a suitable anti-psoriatic drug in the long-term treatment of a chronic disease such as plaque-type psoriasis.

Keywords: psoriasis, nail psoriasis, infliximab, long-term treatment

Creative Commons License © 2009 The Author(s). This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.