Back to Journals » International Journal of General Medicine » Volume 5

Inflammatory status hepatic enzymes and serum creatinine in HIV-, HIV+ and HIV-TB co-infected adult Central Africans

Authors Mokondjimobe, Longo-Mbenza B, Mampouya-Arrouse P, Parra HJ, Diatewa M

Received 24 February 2012

Accepted for publication 22 March 2012

Published 15 November 2012 Volume 2012:5 Pages 961—965


Review by Single-blind

Peer reviewer comments 3

Etienne Mokondjimobe,1,2 Benjamin Longo-Mbenza,3 Patou Mampouya-Arrouse,1 Henri Joseph Parra,1,2 Martin Diatewa1

Laboratory de Biochemistry-Pharmacology, Faculty of Health Sciences, 2National Laboratory of Public Health, Brazzaville, Congo; 3Faculty of Health Sciences, Walter Sisulu University, Mthatha, South Africa

Background and aim: Human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome is a major public health issue in Africa. The objective of this study was to determine which of isolated HIV-infection, isolated naive pulmonary tuberculosis (PTB), or naive HIV-PTB coinfection was more harmful to inflammatory, hepatic, and renal functions.
Methods: This cross-sectional study was undertaken among ten patients with isolated HIV infection, ten patients with isolated naive HIV infection, ten patients with isolated PTB and 32 patients with HIV-PTB coinfection, with the aim of determining which group had the highest levels of oxidative stress and hepatic and renal dysfunction markers. Serum aminotransferase (AST), alanine transferase (ALT), gamma-glutamyl transferase (GGT), and creatinine measurements were compared across the three groups of patients, who were managed from admission in the pulmonology division of the Brazzaville Teaching Hospital, Congo.
Results: HIV patients had the highest levels of ALT, GGT, and creatinine before and after adjusting for age and sex. Adjusted levels of AST, ALT, GGT, and creatinine were higher in HIV-PTB coinfection patients than in sero-negative PTB patients.
Conclusion: There is a significant association between HIV infection and increase in concentration of ALT, GGT, and creatinine.

Keywords: Africa, tuberculosis, HIV-tuberculosis coinfection, renal function

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]


Other articles by this author:

Nadir CD4+, religion, antiretroviral therapy, incidence of type 2 diabetes mellitus, and increasing rates of obesity among black Africans with HIV disease

Mandina Ndona M, Longo-Mbenza B, Wumba R, Tandu Umba B, Buassa-bu-Tsumbu B, Mbula Mambimbi M, Odio Wobin T, Mbungu Fuele S

International Journal of General Medicine 2012, 5:983-990

Published Date: 23 November 2012

Helicobacter pylori infection is identified as a cardiovascular risk factor in Central Africans

Longo-Mbenza B, Nsenga JN, Mokondjimobe E, Gombet T, Assori IN, Ibara JR, Ellenga-Mbolla B, Vangu DN, Fuele SM

Vascular Health and Risk Management 2012, 8:455-461

Published Date: 15 August 2012

Epidemiology, clinical, immune, and molecular profiles of microsporidiosis and cryptosporidiosis among HIV/AIDS patients

Wumba R, Longo-Mbenza B, Menotti J, Mandina M, Kintoki F, Situakibanza NH, Kakicha MK, Zanga J, Mbanzulu-Makola K, Nseka T, Mukendi JP, Kendjo E, Sala J, Thellier M

International Journal of General Medicine 2012, 5:603-611

Published Date: 19 July 2012

Aging, female sex, migration, elevated HDL-C, and inflammation are associated with prevalence of metabolic syndrome among African bank employees

Gombet T, Longo-Mbenza B, Ellenga-Mbolla B, Ikama MS, Mokondjimobe E, Kimbally-Kaky G, Nkoua JL

International Journal of General Medicine 2012, 5:495-503

Published Date: 8 June 2012

Readers of this article also read:

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM

International Journal of Nanomedicine 2014, 9:1883-1889

Published Date: 16 April 2014

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon

Ashwanikumar N, Kumar NA, Nair SA, Kumar GS

International Journal of Nanomedicine 2012, 7:5769-5779

Published Date: 15 November 2012

A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone

Hu Z, Liao M, Chen Y, Cai Y, Meng L, Liu Y, Lv N, Liu Z, Yuan W

International Journal of Nanomedicine 2012, 7:5719-5724

Published Date: 12 November 2012

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010