Inflammatory bowel disease: a focus on the involvement of dietary fats
Punyanganie S de Silva,1,2 Joshua R Korzenik1,2
1Department of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, 2Harvard Medical School, Boston, MA, USA
Abstract: Inflammatory bowel diseases (IBDs) are chronic immune-mediated diseases of the gastrointestinal tract well known to be associated with both genetic and environmental risk factors. Certain genotypes may develop clinical manifestations under particular environmental influences. There is increasing evidence to suggest that diet is a key environmental factor in IBD, and dietary fats in particular have been implicated in both pro- and anti-inflammatory roles. Previous epidemiological studies have highlighted variable results, most probably due to the complex pathways that may be mediated by fatty acid activity. We aim to review the available studies on dietary fats and IBD pathogenesis and explore mechanisms involved to identify potential opportunities for future research and therapies.
Keywords: inflammatory bowel disease, ulcerative colitis, Crohn's disease, lipids, n-3 polyunsaturated fatty acids, n-6 polyunsaturated fatty acids
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