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Infectious bursal disease virus in poultry: current status and future prospects

Authors Alkie TN, Rautenschlein S

Received 11 September 2015

Accepted for publication 18 November 2015

Published 19 January 2016 Volume 2016:7 Pages 9—18


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Professor Young Lyoo

Tamiru Negash Alkie,1 Silke Rautenschlein2

1Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Canada; 2Clinic for Poultry, University of Veterinary Medicine Hannover, Hannover, Germany

Abstract: Infectious bursal disease virus (IBDV) affects immature B lymphocytes of the bursa of Fabricius and may cause significant immunosuppression. It continues to be a leading cause of economic losses in the poultry industry. IBDV, having a segmented double-stranded RNA genome, is prone to genetic variation. Therefore, IBDV isolates with different genotypic and phenotypic diversity exist. Understanding these features of the virus and the mechanisms of protective immunity elicited thereof is necessary for developing vaccines with improved efficacy. In this review, we highlighted the pattern of virus evolution and new developments in prophylactic strategies, mainly the development of new generation vaccines, which will continue to be of interest for research as well as field application in the future.

Keywords: epidemiology, IBDV, immunity, poultry, vaccine

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