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Increased serum IL-17 and decreased serum IL-10 and IL-35 levels correlate with the progression of COPD

Authors Jiang S, Shan F, Zhang Y, Jiang L, Cheng Z

Received 4 March 2018

Accepted for publication 8 June 2018

Published 20 August 2018 Volume 2018:13 Pages 2483—2494

DOI https://doi.org/10.2147/COPD.S167192

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Charles Downs

Peer reviewer comments 3

Editor who approved publication: Prof. Dr. Chunxue Bai


Shenghua Jiang,1,2 Fenglian Shan,2 Youwen Zhang,1,2 Luning Jiang,2 Zhaozhong Cheng1

1Department of Respiratory Medicine, Affiliated Hospital, Qingdao University, Qingdao, China; 2Department of Respiratory Medicine, Affiliated Hospital of Jining Medical University, Jining, China

Purpose: This study aimed to measure the serum levels of interleukin (IL)-17, IL-10, and IL-35 in patients with stable chronic obstructive pulmonary disease (COPD) and disclose the correlations between their expression levels and clinical factors of patients.
Methods: A total of 75 patients with stable COPD (47 males and 28 females) and 30 healthy controls (15 males and 15 females) were included in this study. The serum levels of IL-17, IL-10, and IL-35 were determined by enzyme-linked immunosorbent assay. The correlations between their expression levels and clinical factors of patients were determined using linear regression methods.
Results: The serum level of IL-17 was upregulated in stable COPD, and increased IL-17 expression was positively correlated with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) grading, modified Medical Research Council (mMRC) score, and long clinical history (P<0.05), but negatively correlated with the pulmonary function (P<0.05) of patients. The serum levels of IL-10 and IL-35 were downregulated in stable COPD, and decreased IL-10 and IL-35 levels negatively correlated with the smoking status, GOLD grading, mMRC score, and long clinical history (P<0.05), but positively correlated with the pulmonary function (P<0.05) of patients. Moreover, the level of IL-17 negatively correlated with IL-10 and IL-35, but IL-10 positively correlated with IL-35.
Conclusion: The serum levels of IL-17, IL-10, and IL-35 correlated with the clinical factors of COPD, indicating that they can serve as indicators to estimate the progression of COPD.

Keywords: chronic obstructive pulmonary disease, interleukin-17, interleukin-10, interleukin-35, serum

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