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Increased mean platelet volume in patients with panic disorder

Authors Kokacya MH, Copoglu USC, Kivrak Y, Ari M, Sahpolat M, Ulutas KT

Received 10 August 2015

Accepted for publication 8 September 2015

Published 13 October 2015 Volume 2015:11 Pages 2629—2633

DOI https://doi.org/10.2147/NDT.S94147

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Prof. Dr. Roumen Kirov

Peer reviewer comments 3

Editor who approved publication: Dr Roger Pinder

Mehmet Hanifi Kokacya,1 Umit Sertan Copoglu,1 Yüksel Kivrak,2 Mustafa Ari,1 Musa Sahpolat,1 Kemal Türker Ulutas3

1Department of Psychiatry, Faculty of Medicine, Mustafa Kemal University, Hatay, 2Department of Psychiatry, Faculty of Medicine, Kafkas University, Kars, 3Department of Biochemistry, Kadirli State Hospital, Osmaniye, Turkey

Objective: The relationship between platelet activation and psychiatric disorders has been shown in previous work. Mean platelet volume (MPV) is a measure of platelet size and a good indicator of platelet activity, which increases in cardiovascular diseases (CVDs). It is known that anxiety is a considerable factor in the etiology of mortality in CVDs. The aim of the present study was to investigate any probable difference in the MPV of patients with panic disorder (PD).
Methods: Sixty-one drug-free patients, aged 18–65 years and diagnosed with PD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, were included in the study, along with 63 healthy age- and sex-matched volunteers. The body mass index (BMI) was calculated and MPV measured for each subject.
Results: The MPV was found to be higher in the PD group compared to the control group (P=0.004). There were no significant differences between the two groups in terms of platelet count or BMI.
Conclusion: Alterations in platelet activity may be a reflection of abnormal 5-hydroxytryptamine (5-HT) 1A receptor function in the central nervous system of subjects with a diagnosis of PD. These findings may elucidate the relationship between CVDs and PD. The findings of the present study suggest that MPV is increased in PD patients.

Keywords: mean platelet volume, panic disorder, anxiety

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