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Increased expression of heat shock protein (HSP) 10 and HSP70 correlates with poor prognosis of nasopharyngeal carcinoma

Authors Feng J, Zhan Y, Zhang Y, Zheng H, Wang W, Fan S

Received 5 June 2019

Accepted for publication 5 August 2019

Published 6 September 2019 Volume 2019:11 Pages 8219—8227

DOI https://doi.org/10.2147/CMAR.S218427

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Melinda Thomas

Peer reviewer comments 2

Editor who approved publication: Dr Antonella D'Anneo


Juan Feng,1,2 Yuting Zhan,1 Yuting Zhang,1 Hongmei Zheng,1 Weiyuan Wang,3 Songqing Fan1

1Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China; 2Clinical Laboratory of Hunan Prevention and Treatment Institute for Occupational Diseases, Changsha, Hunan, People’s Republic of China; 3Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China

Correspondence: Songqing Fan
Department of Pathology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, Hunan 410011, People’s Republic of China
Email songqingfan@csu.edu.cn

Background: Heat shock proteins (HSPs) are a large family of chaperones implicating in occurrence and progression of tumor. In our previous study, we found HSP10 correlates with poor prognosis of oral squamous cell carcinoma and astrocytoma. HSP70 is also an important part of this family and whether the alterations of HSP10 and HSP70 expression and their common expression correlates with carcinogenesis and progression of nasopharyngeal carcinoma (NPC) has not been reported.
Method: In this study, we investigate the correlation between the expression of HSP10 and HSP70 and clinicopathological characteristics in NPC by immunohistochemistry (IHC).
Results: Results indicated that positive expression of HSP10 and HSP70 was higher in NPC tissues (both P<0.001). Positive expression of HSP10 and HSP70 proteins, and common positive expression of the two HSPs analyzed in advanced clinical stages were higher than that in early clinical stages (All P<0.05). There was significantly higher expression of HSP10, HSP70, and common expression in NPC with LNM (lymph node metastasis) compared with NPC without LNM (All P<0.05). Interestingly, positive expression of HSP10 and HSP70 proteins and common expression had an evidently inverse correlation with survival status (All P<0.05). Spearman’s correlation analysis showed expression of HSP10 was positively associated with HSP70 (r=0.407, P<0 0.001). Kaplan–Meier analysis showed that the overall survival rates for NPC patients with positive expression of HSP10 and HSP70 and common expression were significantly lower than these patients with negative expression (All P<0.05). Furthermore, positive expression of HSP10 and HSP70 proteins was identified as independent poor prognostic factors for NPC patients (both P<0.05) by Cox regression analysis.
Conclusion: In conclusion, HSP10 and HSP70 can serve as the poor prognostic factors for NPC patients.

Keywords: nasopharyngeal carcinoma, HSP10, HSP70, prognosis
 

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