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Incontinentia pigmenti in a term neonate: an atypical presentation

Authors Gottimukkala SB, Jagalasar M, Sethuraman G, Kitchanan S

Received 25 May 2018

Accepted for publication 17 July 2018

Published 24 October 2018 Volume 2018:8 Pages 65—67

DOI https://doi.org/10.2147/RRN.S175262

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Robert Schelonka


Sasi Bhushan Gottimukkala, Madhu Jagalasar, Giridhar Sethuraman, Srinivasan Kitchanan

Department of Neonatology, Chettinad Hospital & Research Institute, Chennai, Tamil Nadu, India

Abstract: Incontinentia pigmenti is a rare X-linked dominant multi-system disorder that is clinically suspected, based on the characteristic evolution of skin lesions through four stages. We describe a term neonate who presented at birth with pleomorphic skin rashes, including linear hyperpigmented hyperkeratotic lesions and erythematous vesicles, and then developed seizures. She was later histologically and genetically confirmed as a case of incontinentia pigmenti. The simultaneous presence of three stages of skin lesions in the neonatal period is an atypical presentation, which has not been previously well described.

Keywords: incontinentia pigmenti, IKBKG gene, seizures, infant, newborn

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