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Incidence and risk of developing contrast-induced acute kidney injury following intravascular contrast administration in elderly patients

Authors Song W, Zhang T, Pu J, Shen L, He B

Received 30 September 2013

Accepted for publication 16 November 2013

Published 31 December 2013 Volume 2014:9 Pages 85—93


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Wei Song, Tuo Zhang, Jun Pu, Linghong Shen, Ben He

Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China

Background: The purpose of this meta-analysis was to evaluate the epidemiology of contrast-induced acute kidney injury (CI-AKI) in the elderly.
Methods: A literature review was undertaken to determine the incidence of CI-AKI in individuals receiving intravascular contrast medium in the hospital setting.
Results: Twenty-two studies with 186,455 patients were identified. The pooled incidence of CI-AKI was 13.6% in 67,831 patients older than 65 years of age (95% confidence interval [CI] 10.1–18.2, I2=0.496). The pooled odds ratio of CI-AKI in the elderly was 2.55 (95% CI 1.85–3.52, I2=0.34). The high incidence of CI-AKI in the elderly was consistent across different administration route subgroups (intracoronary contrast medium group, 15.5% [95% CI 10.3–22.6]; intravenous contrast medium group, 12.4% [95% CI 8.0–18.8]).
Conclusion: Elderly patients are at greater risk for developing CI-AKI.

Keywords: contrast-induced acute kidney injury, angiography, enhanced computed tomography, epidemiology, meta-analysis

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