Back to Journals » International Journal of Nanomedicine » Volume 7

In vitro characterization and in vivo evaluation of nanostructured lipid curcumin carriers for intragastric administration

Authors Fang M, Jin, Bao, Gao, Xu, Wang, Wang, Yao, Liu

Received 22 July 2012

Accepted for publication 24 August 2012

Published 9 October 2012 Volume 2012:7 Pages 5395—5404


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 6

Min Fang, Yilin Jin, Wei Bao, Hui Gao, Mengjin Xu, Di Wang, Xia Wang, Ping Yao, Liegang Liu

Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, and Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, People’s Republic of China

Background: Curcumin has a variety of pharmacological effects. However, poor water solubility and low oral bioavailability limit its clinical utility. A delivery system for nanostructured lipid carriers has been reported to be a promising approach to enhancing the oral absorption of curcumin. The aim of the present study was to investigate the pharmacokinetics, tissue distribution, and relative bioavailability of curcumin in rats after a single intragastric dose of a nanostructured lipid curcumin carrier formulation.
Methods: Nanostructured lipid curcumin carriers were prepared using the ethanol dripping method and characterized in terms of the particle size, polydispersity index, zeta potential, differential scanning calorimetry, drug-loading capacity, encapsulation efficiency, and in vitro release. The pharmacokinetics and tissue distribution of nanostructured lipid curcumin carriers and curcumin suspension were compared after intragastric administration.
Results: Nanostructured lipid curcumin carriers showed a significantly higher peak plasma concentration (564.94 ± 14.98 ng/mL versus 279.43 ± 7.21 ng/mL, P < 0.01), a shorter time taken to reach peak plasma concentration (0.5 ± 0.01 hour versus 1.0 ± 0.12 hour, P < 0.01), and a greater AUC0–∞ (820.36 ± 25.11 mg × hour/L versus 344.11 ± 10.01 mg × hour/L, P < 0.05) compared with curcumin suspension. In the tissue distribution studies, curcumin could be detected in the spleen, heart, liver, kidneys, lungs, and brain. Following intragastric administration of the nanostructured lipid curcumin carrier formulation, tissue concentrations of curcumin also increased, especially in the brain. The nanostructured lipid curcumin carrier formulation improved the ability of curcumin to cross the blood–brain barrier, with an 11.93-fold increase in the area under the curve achieved in the brain when compared with curcumin suspension.
Conclusion: The nanostructured lipid carrier formulation significantly improved the oral bioavailability of curcumin and represents a promising method for its oral delivery.

Keywords: curcumin, oral bioavailability, tissue distribution

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]


Readers of this article also read:

Heparin nanomodification improves biocompatibility and biomechanical stability of decellularized vascular scaffolds

Tao Y, Hu T, Wu Z, Tang H, Hu Y, Tan Q, Wu C

International Journal of Nanomedicine 2012, 7:5847-5858

Published Date: 26 November 2012

Lactosylated liposomes for targeted delivery of doxorubicin to hepatocellular carcinoma

Zhou X, Zhang M, Yung B, Li H, Zhou C, Lee LJ, Lee RJ

International Journal of Nanomedicine 2012, 7:5465-5474

Published Date: 16 October 2012

Modification of polyethylene glycol onto solid lipid nanoparticles encapsulating a novel chemotherapeutic agent (PK-L4) to enhance solubility for injection delivery

Fang YP, Wu PC, Huang YB, Tzeng CC, Chen YL, Hung YH, Tsai MJ, Tsai YH

International Journal of Nanomedicine 2012, 7:4995-5005

Published Date: 17 September 2012

Sustained-release G-CSF microspheres using a novel solid-in-oil-in-oil-in-water emulsion method

Liu G, Hong X, Jiang M, Yuan W

International Journal of Nanomedicine 2012, 7:4559-4569

Published Date: 17 August 2012

Echographic detectability of optoacoustic signals from low-concentration PEG-coated gold nanorods

Conversano F, Soloperto G, Greco A, Ragusa A, Casciaro E, Chiriacò F, Demitri C, Gigli G, Maffezzoli A, Casciaro S

International Journal of Nanomedicine 2012, 7:4373-4389

Published Date: 9 August 2012

Improved pharmacokinetics and reduced toxicity of brucine after encapsulation into stealth liposomes: role of phosphatidylcholine

Chen J, Yan GJ, Hu RR, Gu QW, Chen ML, Gu W, Chen ZP, Cai BC

International Journal of Nanomedicine 2012, 7:3567-3577

Published Date: 26 July 2012

Nanoinformatics: a new area of research in nanomedicine

Maojo V, Fritts M, de la Iglesia D, Cachau RE, Garcia-Remesal M, Mitchell JA, Kulikowski C

International Journal of Nanomedicine 2012, 7:3867-3890

Published Date: 24 July 2012

Highly efficient magnetic targeting of mesenchymal stem cells in spinal cord injury

Vaněček V, Zablotskii V, Forostyak S, Růžička J, Herynek V, Babič M, Jendelová P, Kubinová Š, Dejneka A, Syková E

International Journal of Nanomedicine 2012, 7:3719-3730

Published Date: 16 July 2012