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In situ fabrication of silver nanoparticle-filled hydrogen titanate nanotube layer on metallic titanium surface for bacteriostatic and biocompatible implantation

Authors Wang Z, Sun Y, Wang DZ, Liu H, Boughton RI

Received 26 March 2013

Accepted for publication 10 May 2013

Published 7 August 2013 Volume 2013:8(1) Pages 2903—2916

DOI https://doi.org/10.2147/IJN.S45742

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Zheng Wang,1 Yan Sun,1 Dongzhou Wang,2 Hong Liu,2 Robert I Boughton3

1Department of Cardiology, Heilongjiang Provincial Hospital, Haerbin, Heilongjiang, People’s Republic of China; 2State Key Laboratory of Crystal Materials, Shandong University, Jinan, People’s Republic of China; 3Department of Physics and Astronomy, Bowling Green State University, Bowling Green, OH, USA

Abstract: A silver nanoparticle (AgNP)-filled hydrogen titanate nanotube layer was synthesized in situ on a metallic titanium substrate. In the synthesis approach, a layer of sodium titanate nanotubes is first prepared on the titanium surface by using a hydrothermal method. Silver nitrate solution is absorbed into the nanotube channels by immersing a dried nanotube layer in silver nitrate solution. Finally, silver ions are reduced by glucose, leading to the in situ growth of AgNPs in the hydrogen titanate nanotube channels. Long-term silver release and bactericidal experiments demonstrated that the effective silver release and effective antibacterial period of the titanium foil with a AgNP-filled hydrogen titanate nanotube layer on the surface can extend to more than 15 days. This steady and prolonged release characteristic is helpful to promote a long-lasting antibacterial capability for the prevention of severe infection after surgery. A series of antimicrobial and biocompatible tests have shown that the sandwich nanostructure with a low level of silver loading exhibits a bacteriostatic rate as high as 99.99%, while retaining low toxicity for cells and possessing high osteogenic potential. Titanium foil with a AgNP-filled hydrogen titanate nanotube layer on the surface that is fabricated with low-cost surface modification methods is a promising implantable material that will find applications in artificial bones, joints, and dental implants.

Keywords: titanium implant, silver nanoparticle filling, ion substitution, bacteriostasis, cytocompatibility

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