Back to Archived Journals » Current Biomarker Findings » Volume 5

Improving tuberculosis diagnostics with biomarkers

Authors Shu C, Wang J, Lee L, Yu C, Luh K

Received 7 January 2015

Accepted for publication 14 February 2015

Published 7 May 2015 Volume 2015:5 Pages 13—19

DOI https://doi.org/10.2147/CBF.S41651

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Dr Hung Khong


Chin-Chung Shu,1,2 Jann-Yuan Wang,2 Li-Na Lee,2,3 Chong-Jen Yu,2 Kwen-Tay Luh3

1Department of Traumatology, 2Department of Internal Medicine, 3Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan

Abstract: Although many laboratory methods have been developed to expedite the diagnosis of active tuberculosis (TB) and Mycobacterium tuberculosis (Mtb) infection, delays in diagnosis remain a major problem in clinical practice. Biomarkers may contribute favorably or unfavorably to TB diagnosis in a clinical suspect TB case with inconclusive diagnostic findings. A good understanding of the effectiveness and practical limitations of these biomarkers is important to improve diagnosis. This review summarizes currently used biomarkers, mainly as validation, and focuses on latent TB infection, active pulmonary TB, and tuberculous pleural effusion.

Keywords: tuberculosis, biomarker, diagnosis, latent tuberculosis infection, pleural effusion
 

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]