Back to Journals » International Journal of Nanomedicine » Volume 9 » Issue 1

Improved absorption and in vivo kinetic characteristics of nanoemulsions containing evodiamine–phospholipid nanocomplex

Authors Hu J, Chen D, Jiang R, Tan Q, Zhu B, Zhang J

Received 27 December 2013

Accepted for publication 10 March 2014

Published 17 September 2014 Volume 2014:9(1) Pages 4411—4420


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Jiangbo Hu,1,* Dilong Chen,2,* Rong Jiang,2 Qunyou Tan,3 Biyue Zhu,4 Jingqing Zhang1

1Medicine Engineering Research Center, Chongqing Medical University, Chongqing, People's Republic of China; 2Department of Histology and Embryology, Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, 3Department of Thoracic Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, 4West China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China

*These authors contributed equally to this work

Purpose: The purpose of this study was to assess the improved absorption and in vivo kinetic characteristics of a novel water-in-oil nanoemulsion containing evodiamine–phospholipid nanocomplex (NEEPN) when administered orally.
Methods: NEEPN was fabricated by loading an evodiamine–phospholipid nanocomplex into a water-in-oil nanoemulsive system. The gastrointestinal absorption of NEEPN was investigated using an in situ perfusion method. The modified in vivo kinetic characteristics of evodiamine (EDA) in NEEPN were also evaluated.
Results: Compared with EDA or conventional nanoemulsions containing EDA instead of evodiamine–phospholipid complex, NEEPN with its favorable in vivo kinetic characteristics clearly enhanced the gastrointestinal absorption and oral bioavailability of EDA; for example, the relative bioavailability of NEEPN to free EDA was calculated to be 630.35%, and the effective permeability of NEEPN in the colon was 8.64-fold that of EDA.
Conclusion: NEEPN markedly improved the oral bioavailability of EDA, which was probably due to its increased gastrointestinal absorption. NEEPN also increased efficacy and reduced adverse effects for oral delivery of EDA. Such finding demonstrates great clinical significance as an ideal drug delivery system demands high efficacy and no adverse effects.

Keywords: nanoemulsive system, evodiamine–phospholipid, nanocomplexes, gastrointestinal absorption, oral bioavailability, water-in-oil

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]