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Importance and management of micronutrient deficiencies in patients with Alzheimer’s disease

Authors Cardoso BR, Cominetti C, Cozzolino SMF

Received 16 November 2012

Accepted for publication 9 March 2013

Published 10 May 2013 Volume 2013:8 Pages 531—542

DOI https://doi.org/10.2147/CIA.S27983

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Bárbara Rita Cardoso,1 Cristiane Cominetti,2 Silvia Maria Franciscato Cozzolino1

1
Faculty of Pharmaceutical Sciences, University of São Paulo (USP), São Paulo, Brazil; 2Faculty of Nutrition, Federal University of Goiás, Goiás, Brazil

Abstract: Alzheimer’s disease (AD) is the most common form of dementia, and it generally affects the elderly. It has been suggested that diet is an intensively modifiable lifestyle factor that might reduce the risk of AD. Because epidemiological studies generally report the potential neuronal protective effects of various micronutrients, the aim of this study was to perform a literature review on the major nutrients that are related to AD, including selenium, vitamins C and E, transition metals, vitamin D, B-complex vitamins, and omega-3 fatty acids.

Keywords: Alzheimer’s disease, nutritional deficiencies, diet, oxidative stress, lipid, vitamins

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