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Impact of ST-segment elevation on the outcome of Takotsubo syndrome

Authors Gietzen T, El-Battrawy I, Lang S, Zhou X, Behnes M, Ansari U, Borggrefe M, Akin I

Received 13 July 2018

Accepted for publication 9 October 2018

Published 7 February 2019 Volume 2019:15 Pages 251—258


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Professor Garry Walsh

Thorsten Gietzen,1,2,* Ibrahim El-Battrawy,1,2,* Siegfried Lang,1,2 Xiao-Bo Zhou,1,2 Michael Behnes,1 Uzair Ansari,1 Martin Borggrefe,1,2 Ibrahim Akin1,2

1First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany; 2German Center for Cardiovascular Research (DZHK), Partner Site, Heidelberg-Mannheim, Mannheim, Germany

*These authors contributed equally to this work

Background: Recent studies have highlighted that Takotsubo syndrome (TTS), mimicking acute coronary syndrome (ACS), is associated with poor clinical outcome. TTS is associated with different repolarization disorders including ST-segment elevation. ST elevation myocardial infarction (STEMI) in ACS is associated with declined prognosis. However, the clinical and prognostic impact of ST-segment elevation on TTS remains lacking.
Aim: The aim of this study was to determine the short- and long-term prognostic impact of ST-segment elevation on TTS patients as compared with STEMI patients.
Patients and methods: Our institutional database constituted a consecutive cohort of 138 TTS patients and 138 ACS patients matched for age and sex. TTS patients (n=41) with ST-segment elevation were compared with ACS patients with ST-segment elevation (n=64).
Results: Chest pain was significantly more documented in STEMI patients as compared with TTS patients (48.8% vs 78.1%; P<0.01). Cardiovascular risk factors such as diabetes mellitus (12.2% vs 29.7%; P=0.02) were significantly more presented in STEMI patients. Although the initial left ventricular ejection fraction (LVEF) was more declined in TTS patients (39%±9% vs 45%±16%; P<0.01), the LVEF was more declined in STEMI patients at follow-up (54%±10% vs 45%±16%; P=0.04). Inhospital complications such as respiratory failure were significantly more presented in TTS patients (68.3% vs 20.3%; P<0.01). The short-term as well as the long-term morality was similar in both groups. In univariate analysis, male sex, ejection fraction (EF) <35%, glomerular filtration rate (GFR) ,60 mL/min, cardiogenic shock, inotropic drugs, and history of cancer were predictors of 5-year mortality.
Conclusion: Rates of the long-term mortality in TTS patients with ST elevations are comparable with STEMI patients.

Keywords: Takotsubo syndrome, coronary artery syndrome, prognosis, ST elevation

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