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Impact of mirabegron extended-release on the treatment of overactive bladder with urge urinary incontinence, urgency, and frequency

Authors Lee R, Bamberger M, Ellsworth P

Received 1 August 2013

Accepted for publication 5 September 2013

Published 25 October 2013 Volume 2013:5 Pages 147—157


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Raymond T Lee,1 Mitchell Bamberger,2 Pamela Ellsworth3

1University of Massachusetts Medical School, 2UMass Memorial Medical Center, University of Massachusetts Medical School, Worcester, MA, 3Division of Urology/Surgery, Warren Alpert Medical School of Brown University, Providence, RI, USA

Abstract: Overactive bladder is a highly prevalent disorder with a significant impact on quality of life. Antimuscarinic agents are commonly used, but persistence is limited due to unsatisfactory efficacy and/or tolerability. Mirabegron is the first beta-3 adrenoceptor agonist approved for the treatment of overactive bladder syndrome. This paper reviews the pharmacology, mechanism of action, efficacy, and safety of mirabegron. A PubMed search of all English articles pertaining to mirabegron was performed. An alternative to antimuscarinics, mirabegron has a unique mechanism, improves overactive bladder symptoms and quality of life, and has limited adverse effects and few contraindications.

Keywords: overactive bladder, incontinence, beta-3 agonist, mirabegron

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