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Impact of diabetes mellitus on the risk and survival of nasopharyngeal carcinoma: a meta-analysis

Authors Guo G, Fu M, Wei S, Chen R

Received 21 September 2017

Accepted for publication 18 December 2017

Published 2 March 2018 Volume 2018:11 Pages 1193—1201

DOI https://doi.org/10.2147/OTT.S152217

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Ingrid Espinoza


Gang Guo,1,* Moushun Fu,2,* Shuxiang Wei,3 Ruiwan Chen4

1Department of Ophthalmology, Tongjiang Hospital of Guangdong, Foshan, 2Department of Otorhinolaryngology, Tongjiang Hospital of Guangdong, Foshan, 3Department of Endocrinology, Tongjiang Hospital of Guangdong, Foshan, 4Department of Radiotherapy, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

*These authors contributed equally to this work

Background: Diabetes mellitus (DM) has been identified to be both a risk factor and a prognostic factor in a variety of malignancies, but its association with the risk and outcome of nasopharyngeal carcinoma (NPC) is still unclear. To elucidate this issue, we systematically reviewed the evidence concerning the association between DM status and NPC.
Materials and methods: We identified studies by a literature search of PubMed, Embase, and ISI Web of Knowledge through May 31, 2017, and by searching the reference lists of pertinent articles. Odds ratios (ORs) and hazard ratios (HRs) with 95% CIs were used to estimate the effect size. Heterogeneity across studies was evaluated by the Cochran’s Q and I2 statistics.
Results: A total of nine studies were included. Four studies with a total sample size of 221,611 reported the effect of DM on NPC risk, and the other five studies with a sample size of 9,442 reported the impact of DM on survival in NPC patients. All included studies were retrospective, and mostly conducted in Asian populations. Meanwhile, condition of metformin usage was not considered in all studies. A pooled OR of 0.65 (95% CI: 0.43–0.98, P=0.04) revealed an inverse association between DM and NPC. Additionally, pooled analyses of studies investigating the prognosis value of DM revealed that preexisting DM had no effect on overall survival (HR =1.17, 95% CI: 0.94–1.46, P=0.16), local recurrence-free survival (HR =1.16, 95% CI: 0.80–1.67, P=0.44), and distant metastasis-free survival (HR =1.14, 95% CI: 0.92–1.40, P=0.22).
Conclusion: Our results suggested that DM patients might have decreased NPC risk, and have little impact on prognosis of NPC patients. This conclusion should be limited to Asian population. Our results also suggest that more attention should be paid to metformin medication in further studies in order to clarify whether the effects of DM on NPC risk and prognosis are influenced by the anticancer effect of metformin.

Keywords: diabetes mellitus, nasopharyngeal carcinoma, risk factor, prognosis factor, a meta-analysis, evidence based medicine
 

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