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Immunotherapy for tuberculosis: future prospects

Authors Abate G, Hoft D

Received 24 November 2015

Accepted for publication 27 January 2016

Published 20 April 2016 Volume 2016:5 Pages 37—45

DOI https://doi.org/10.2147/ITT.S81892

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Federico Perche

Peer reviewer comments 5

Editor who approved publication: Professor Michael Shurin


Getahun Abate,1 Daniel F Hoft1,2

1Department of Internal Medicine, Division of Infectious Diseases, Allergy and Immunology, 2Department of Molecular Microbiology and Immunology, Saint Louis University, St. Louis, MO, USA

Abstract: Tuberculosis (TB) is still a major global health problem. A third of the world's population is infected with Mycobacterium tuberculosis. Only ~10% of infected individuals develop TB but there are 9 million TB cases with 1.5 million deaths annually. The standard prophylactic treatment regimens for latent TB infection take 3–9 months, and new cases of TB require at least 6 months of treatment with multiple drugs. The management of latent TB infection and TB has become more challenging because of the spread of multidrug-resistant and extremely drug-resistant TB. Intensified efforts to find new TB drugs and immunotherapies are needed. Immunotherapies could modulate the immune system in patients with latent TB infection or active disease, enabling better control of M. tuberculosis replication. This review describes several types of potential immunotherapies with a focus on those which have been tested in humans.

Keywords: tuberculosis, HDT, immunotherapy, treatment

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