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Immunotherapy for the Treatment of Breast Cancer: Emerging New Data

Authors Mina LA, Lim S, Bahadur SW, Firoz AT

Received 26 September 2019

Accepted for publication 12 December 2019

Published 3 January 2020 Volume 2019:11 Pages 321—328


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Pranela Rameshwar

Lida A Mina,1 Shannon Lim,2 Shakeela W Bahadur,1 Abdul T Firoz3

1Hematology Oncology Department, Banner MD Anderson Cancer Center, Gilbert, AZ, USA; 2Pharmacy Department, Banner MD Anderson Cancer Center, Gilbert, AZ, USA; 3Science Department, Arizona State University, Tempe, AZ, USA

Correspondence: Lida A Mina
Banner MD Anderson Cancer Center, Suite 400, 2946 E Banner Gateway Dr, Gilbert, AZ 85234, USA
Tel +1 480 256 3676
Fax +1 480 256 4624

Abstract: Breast cancer is the most common type of cancer affecting women in the United States. Triple-negative breast cancer remains the most aggressive molecular subtype secondary to a lack of therapeutic targets. The search for a target has led us to investigate immunotherapeutic agents. Immunotherapy has recently demonstrated significant breakthroughs in various types of cancers that are refractory to traditional therapies including melanoma and Non-Small Cell Lung Cancer (NSCLC). Breast cancer however remains one of the tumors that was initially least investigated because of being considered to have a low immunogenic potential and a low mutational load. Over the past few years, antiPD1/PDL1 drugs have started to make progress in the triple-negative subtype with more promising outcomes. In this report, we review the treatment of triple-negative breast cancer and specifically shed light on advances in immunotherapy and newly approved drugs in this challenging disease.

Keywords: breast cancer, immunotherapy, PD1, PDL1, atezolizumab

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