Back to Journals » Clinical, Cosmetic and Investigational Dermatology » Volume 4

Imaging of melanoma: usefulness of ultrasonography before and after contrast injection for diagnosis and early evaluation of treatment

Authors Chami L, Lassau N, Chebil M, Robert C

Published 8 February 2011 Volume 2011:4 Pages 1—6


Review by Single anonymous peer review

Peer reviewer comments 3

Linda Chami1,2, Nathalie Lassau1,2, Mohamed Chebil1, Caroline Robert3
1Imaging Department Institut Gustave Roussy, Villejuif, France; 2IR4M (UMR8081), University Paris-Sud-CNRS Orsay, France; 3Dermatology, Institut Gustave Roussy, Villejuif, France

Abstract: High-frequency ultrasound (8–14 MHz) is routinely used to display cutaneous melanomas. Maximum thickness measurement (Breslow index) has been shown to be well correlated to histologic findings for lesions of more than 0.75 mm. Some morphological criteria (strong delineation, hypoechoic texture, homogeneity) have been reported to help differentiate between malignant and benign pigmented blue lesions, but remain insufficient. Vascular ultrasound analysis using Doppler mode provides additional information and showed good specificity for malignancy (90%–100%), but variable sensitivity (34%–100%). Recent advances in ultrasound imaging allow functional evaluation. Likewise, dynamic contrast-enhanced ultrasound using contrast medium injection and specific perfusion and quantification software showed promising results in clinical and preclinical trials for early prediction of tumor response to target treatments.

Keywords: melanoma, ultrasound, dynamic contrast-enhanced ultrasound

Creative Commons License © 2011 The Author(s). This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.