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Identifying patients at high risk of breast cancer recurrence: strategies to improve patient outcomes

Authors Martei Y, Matro J

Received 8 July 2015

Accepted for publication 17 August 2015

Published 8 October 2015 Volume 2015:7 Pages 337—343

DOI https://doi.org/10.2147/BCTT.S91981

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Tuhin Das

Peer reviewer comments 2

Editor who approved publication: Professor Pranela Rameshwar

Yehoda M Martei,1 Jennifer M Matro1,2

1Department of Medicine, Hematology-Oncology Division, 2Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA

Abstract: Identifying patients at high risk of breast cancer recurrence has important implications not only for enabling the ability to provide accurate information to patients but also the potential to improve patient outcomes. Patients at high recurrence risk can be offered appropriate treatment to improve the overall survival. However, the major challenge is identifying patients with early-stage breast cancer at lower risk who may be spared potentially toxic therapy. The successful integration of molecular assays into clinical practice may address the problem of overtreatment and improve overall patient outcomes.

Keywords: breast cancer, early stage, genomic assays, recurrence risk, recurrence score

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