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Identification of significant genes in genomics using Bayesian variable selection methods

Authors Lin E, Huang L

Published 1 July 2008 Volume 2008:1 Pages 13—18


Review by Single-blind

Peer reviewer comments 3

Eugene Lin1, Lung-Cheng Huang2,3

1Vita Genomics, Inc., Wugu Shiang, Taipei, Taiwan; 2Department of Psychiatry, National Taiwan University Hospital Yun-Lin Branch, Taiwan; 3Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

Abstract: In the studies of genomics, it is essential to select a small number of genes that are more significant than the others for research ranging from candidate gene studies to genome-wide association studies. In this study, we proposed a Bayesian method for identifying the promising candidate genes that are significantly more influential than the others. We employed the framework of variable selection and a Gibbs sampling based technique to identify significant genes. The proposed approach was applied to a genomics study for persons with chronic fatigue syndrome. Our studies show that the proposed Bayesian methodology is effective for deriving models for genomic studies and for providing information on significant genes.

Keywords: Bayesian variable selection, genomics, Gibbs sampling, variable selection

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