Ibuprofen-loaded poly(lactic-co-glycolic acid) films for controlled drug release

Jianmei Pang¹, Yuxia Luan¹, Feifei Li¹, Xiaoqing Cai¹, Jimin Du², Zhonghao Li^3
1School of Pharmaceutical Science, Shandong University, Jinan, Shandong Province, PR China; ²School of Chemistry and Chemical Engineering, Anyang Normal University, Henan Province, PR China; ³School of Materials Science and Engineering, Shandong University, Jinan, Shandong Province, PR China

Abstract: Ibuprofen- (IBU) loaded biocompatible poly(lactic-co-glycolic acid) (PLGA) films were prepared by spreading polymer/ibuprofen solution on the nonsolvent surface. By controlling the weight ratio of drug and polymer, different drug loading polymer films can be obtained. The synthesized ibuprofen-loaded PLGA films were characterized with scanning electron microscopy, powder X-ray diffraction, and differential scanning calorimetry. The drug release behavior of the as-prepared IBU-loaded PLGA films was studied to reveal their potential application in drug delivery systems. The results show the feasibility of the as-obtained films for controlling drug release. Furthermore, the drug release rate of the film could be controlled by the drug loading content and the release medium. The development of a biodegradable ibuprofen system, based on films, should be of great interest in drug delivery systems.

Keywords: ibuprofen, controlled release, poly(lactic-co-glycolic acid), films