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Hypothesis: What is the Best We Can Do with Hydroxychloroquine for COVID-19?

Authors Wang S, Mulier S, Jonscher C, Ye S, Chen L, Feng Y, Li Y, Ni Y

Received 20 August 2020

Accepted for publication 21 September 2020

Published 20 October 2020 Volume 2020:12 Pages 1139—1144

DOI https://doi.org/10.2147/CLEP.S277889

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Vera Ehrenstein


Shuncong Wang,1,* Stefaan Mulier,1,2,* Charles Jonscher,3 Sheng Ye,4 Lei Chen,1 Yuanbo Feng,1 Yue Li,5 Yicheng Ni1

1Campus Gasthuisberg, Group of Biomedical Sciences, KU, Leuven, Belgium; 2Department of Surgery, Delta Hospital, Brussels, Belgium; 3Institute for Health Metrics & Evaluation, University of Washington, Seattle, WA, USA; 4Primary Care NJ, Englewood, NJ, USA; 5Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai 201318, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Yicheng Ni
Department of Radiology, University Hospital, Herestraat 49, Leuven B3000, Belgium
Tel +32-16-32 27 52
Fax + 32-16-34 37 65
Email [email protected]

Abstract: There are widespread anecdotal reports of seemingly successful treatment among the early (three to seven days from symptoms) stage coronavirus disease 2019 (COVID-19) patients with the drug hydroxychloroquine (HCQ), and randomized placebo-controlled trials of HCQ in outpatient settings are underway. In this note, we (1) report observational evidence and present scientific reasoning as to why early treatment with HCQ may succeed while treatment later in the disease progression is likely to fail and (2) hypothesize a public health regime under which HCQ may be used to mitigate the impact of the current pandemic.

Keywords: COVID-19, pandemic, early treatment, hydroxychloroquine, lockdown

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