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Hydrogen-rich saline may be an effective and specific novel treatment for osteoradionecrosis of the jaw

Authors Chen Y, Zong C, Guo Y, Tian L

Received 19 June 2015

Accepted for publication 5 August 2015

Published 14 October 2015 Volume 2015:11 Pages 1581—1585

DOI https://doi.org/10.2147/TCRM.S90770

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Hoa Le

Peer reviewer comments 3

Editor who approved publication: Professor Deyun Wang

Yuanli Chen, Chunlin Zong, Yuxuan Guo, Lei Tian

Department of Cranio-facial Trauma and Orthognathic Surgery Laboratory of Military Stomatology, School of Stomatology, The Fourth Military Medical University, Shaanxi Key Laboratory of Stomatology, Xi’an, People’s Republic of China

Abstract: Hydrogen, a therapeutic medical gas, can exert antioxidant activity via selectively reducing cytotoxic reactive oxygen species such as hydroxyl radicals. Hydrogen-rich saline is an alternative form of molecular hydrogen that has been widely used in many studies, including metabolic syndrome, cerebral, hepatic, myocardial ischemia/reperfusion, and liver injuries with obstructive jaundice, with beneficial results. Osteoradionecrosis of the jaw is a serious complication following radiotherapy for head and neck cancers. It has long been known that most radiation-induced symptoms are caused by free radicals generated by radiolysis of H2O, and the hydroxyl radical is the most reactive of these. Reducing the hydroxyl radical can distinctly improve the protection of cells from radiation damage. We hypothesized that hydrogen-rich saline might be an effective and specific method of managing and preventing osteoradionecrosis of the jaw.

Keywords: osteoradionecrosis, hydrogen, reactive oxygen species

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