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Hydrogels For Peptide Hormones Delivery: Therapeutic And Tissue Engineering Applications

Authors Doostmohammadi M, Ameri A, Mohammadinejad R, Dehghannoudeh N, Banat IM, Ohadi M, Dehghannoudeh G

Received 26 May 2019

Accepted for publication 2 September 2019

Published 26 September 2019 Volume 2019:13 Pages 3405—3418

DOI https://doi.org/10.2147/DDDT.S217211

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 3

Editor who approved publication: Dr Qiongyu Guo


Mohsen Doostmohammadi,1 Atefeh Ameri,1 Reza Mohammadinejad,1 Negar Dehghannoudeh,2 Ibrahim M Banat,3 Mandana Ohadi,1 Gholamreza Dehghannoudeh1,4

1Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran; 2Faculty of Arts and Science, University of Toronto, Toronto M5S3G3, Ontario, Canada; 3School of Biomedical Sciences, Faculty of Life & Health Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK; 4Department of Pharmaceutics, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran

Correspondence: Mandana Ohadi; Gholamreza Dehghannoudeh
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
Tel +98 34 31325243; +98 34 31325014
Fax +98 34 31325003
Email mandanaohady@gmail.com; ghr_dehghan@kmu.ac.ir

Abstract: Peptides are the most abundant biological compounds in the cells that act as enzymes, hormones, structural element, and antibodies. Mostly, peptides have problems to move across the cells because of their size and poor cellular penetration. Therefore, a carrier that could transfer peptides into cells is ideal and would be effective for disease treatment. Until now, plenty of polymers, e.g., polysaccharides, polypeptides, and lipids were used in drug delivery. Hydrogels made from polysaccharides showed significant development in targeted delivery of peptide hormones because of their natural characteristics such as networks, pore sizes, sustainability, and response to external stimuli. The main aim of the present review was therefore, to gather the important usages of the hydrogels as a carrier in peptide hormone delivery and their application in tissue engineering and regenerative medicine.

Keywords: hydrogels, peptides hormones, tissue engineering, drug delivery

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