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Hormonal contraception and HPV: a tale of differing and overlapping mechanisms

Authors Marks M, Sabra Klein, Gravitt P

Published 22 November 2011 Volume 2011:2 Pages 161—174

DOI https://doi.org/10.2147/OAJC.S17404

Review by Single-blind

Peer reviewer comments 2


Morgan A Marks1, Sabra L Klein2,3, Patti E Gravitt1,2
1Department of Epidemiology, 2W Harry Feinstone Department of Molecular Microbiology and Immunology, 3Department of Biochemistry and Molecular Biology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

Abstract: Hormonal contraceptive use is an identified co-factor that modifies cervical cancer risk. The mechanisms by which sex steroid hormones affect the multi-stage natural history of human papillomavirus (HPV) infection and cervical carcinogenesis are still unclear, with no consistent evidence in support of a single biological hypothesis. Understanding the means by which hormonal contraception affects HPV infection and cervical cancer risk may provide critical information to guide future secondary interventions for cancer prevention.

Keywords: hormones, human papillomavirus, cervical cancer

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