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Histopathologic correlation of Aspergillus endophthalmitis following uncomplicated cataract surgery

Authors Haddock LJ, Flynn Jr. H, Dubovy S, Khurana R, Egbert P

Received 27 June 2012

Accepted for publication 20 July 2012

Published 25 September 2012 Volume 2012:6 Pages 1573—1577


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Luis J Haddock,1 Harry W Flynn Jr,1 Sander R Dubovy,1 Rahul N Khurana,2 Peter R Egbert3

1Department of Ophthalmology, Bascom Palmer Eye Institute, Miami Miller School of Medicine, Miami, FL, 2Northern California Retina Vitreous Associates, Mountain View, CA, 3Department of Ophthalmology, The Byers Eye Institute at Stanford, Stanford University, Palo Alto, CA, USA

Abstract: A clinicopathologic correlation between two patients with acute-onset Aspergillus endophthalmitis undergoing enucleation is reported. These two patients presented with pain, redness, and decreased vision following uncomplicated cataract surgery. In both patients, vitreous aspiration and intravitreal injections were the initial treatment followed later by pars plana vitrectomy for clinical worsening. Despite repeated surgical and medical interventions, the clinical course of both patients was prolonged, unsuccessful, and resulted in enucleation for a blind painful eye. Histologic examination of the enucleated specimens showed that, in spite of prolonged local and systemic therapy, there was persistent diffuse infiltration of the anterior chamber and ciliary body by a filamentous mold.

Keywords: mold, enucleation, voriconazole, amphotericin B

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